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Minimal residual disease in solid tumors: an overview

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 649-674 doi: 10.1007/s11684-023-1018-6

Abstract: Minimal residual disease (MRD) is termed as the small numbers of remnant tumor cells in a subset of patientstechniques, and strategies for the detection of cancer, and emphasizes the application of MRD detection in solid

Keywords： MRD     solid tumor     CTC     ctDNA    

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or theyThe simultaneous expression of target antigens by healthy organs and tumor cells is partly responsibleAlongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associatedantigens can also minimize the off-tumor effects of CAR-T therapies.Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis,

Keywords： cancer immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation    

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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 333-344 doi: 10.1007/s11705-021-2059-5

Abstract: ., long-lasting and/or systemic anti-tumor immunity.perspective first discusses the temperature-gradient and the spatially-structured immunological landscape in solidorder to propagate the immune activation as a viable therapeutic principle, we further discussed the tumortype-specific complexity in the immunological tumor microenvironment, including the creative design

Keywords： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: However, CAR T cells have achieved minimal success against solid malignancies because of the additionalon the recent advances in the engineering of CAR T cell therapies to restore the immune response in solidwe discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhance the anti-tumoroutcomes of CAR T cell therapies in solid tumors.

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 383-403 doi: 10.1007/s11684-020-0818-1

Abstract: interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumorThe signal−moonlighting protein−metabolism axis facilitates the adaptation of tumor cells under varying

Keywords： moonlighting function     tumor metabolism     epigenetics    

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Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 426-439 doi: 10.1007/s11684-018-0663-7

Abstract:

Tumor microenvironment (TME) is comprised of cellular and non-cellular components that exist withinand around the tumor mass.Given the importance of TME in tumor progression and therapy resistance, strategies that remodel TME

Keywords： tumor microenvironment     therapy response     treatment resistance    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: However, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cellSingle-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected fromM2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumorImmunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansionThus, our findings provided a clinical rationale for targeting tumor microenvironments and reprogramming

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment     tumor-associated macrophage     metabolism    

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Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 67-78 doi: 10.1007/s11684-012-0176-8

Abstract: Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor, which fosters tumor cells to become more aggressive and metastatic.on the pioneering work on tumor blood vessels by several other researchers.roles in tumor neovascularization, growth, and metastasis.Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor

Keywords： angiogenesis     vasculogenesis     neovascularization     tumor     vasculature     normalization     traditional Chinese medicine    

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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract: genetically modifying NK cell lines by increasing their expression of cytokines and engineering chimeric tumorIn this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell     natural killer cell line     tumor immunotherapy     genetic modification    

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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety

Keywords： vaccine     nanoparticle     tumor     immunotherapy     microenvironment    

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carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4,   Pages 536-545 doi: 10.1007/s11705-021-2067-5

Abstract: recurrence after tumor resection, both free BCNU and BCNU- poly (lactic-co-glycolic acid) (the ratioThe hydrogel was injected into the resection cavity of a glioblastoma tumor immediately after tumor removalFree drugs were released instantly to kill the residual tumor cells, while drugs in nanoparticles werecontinuously released to achieve a continuous and effective inhibition of the residual tumor cells forThese combined actions effectively restricted tumor growth in rats.

Keywords： BCNU     glioblastoma recurrence     tumor resection     nanoparticles     hydrogel    

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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: Tumor growth is an angiogenesis-dependent process and accompanied by the formation of hypoxic areas.Tumstatin is a tumor-specific angiogenesis inhibitor that suppresses the proliferation and induces theattenuated Salmonella typhimurium strain, preferentially accumulates in the hypoxic areas of solidTreatment with VNP-Tum5 effectively suppressed tumor growth and prolonged survival in the mouse modelof melanoma by combining anti-tumor and anti-angiogenic effects.

Keywords： Salmonella VNP20009     tumstatin     B16F10     melanoma     apoptosis     angiogenesis    

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Endostatin specifically targets both tumor blood vessels and lymphatic vessels

Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 336-340 doi: 10.1007/s11684-011-0163-5

Abstract: Recently, several studies demonstrated that endostatin also inhibits tumor lymphangiogenesis and lymphatic

Keywords： endostatin     angiogenesis     lymphangiogenesis     nystatin     internalization     tumor    

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Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 49-56 doi: 10.1007/s11684-009-0012-y

Abstract: The aim of this paper was to study the differential gene expression of giant cell tumor of bone (GCTB

Keywords： giant cell tumor of bone     gene     microarray     cDNA    

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Title Author Date Type Operation

Minimal residual disease in solid tumors: an overview

Journal Article

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Journal Article

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qunying Lei

Journal Article

Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives

Bingxue Shang, Zhifei Cao, Quansheng Zhou

Journal Article

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Journal Article

carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor

Journal Article

Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Journal Article

Endostatin specifically targets both tumor blood vessels and lymphatic vessels

Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo

Journal Article

Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Journal Article